I did the junior version with my DCD second and third graders, and as a game reward for one of my lower LD groups. They worked on finding the differences (the concepts same/different), labeling the animals (we didn't have them all), and big/small (also bigger/smaller) since the item sizes vary so much. With these kids we took turns finding the difference, since one was able to find it right away, and the other was either taking more time or being his contrary self... (Either way he had to do the work.) I see myself adding over and under to our concepts when using this in the future.
Spot It is a super fun and easy activity. I highly recommend these if you don't already have them. As a bonus, they meet the criteria for small and portable and if you travel it will be a great lightweight addition to your bag.